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Cernos 1% gel is used in the treatment of male hypogonadism. It treats the symptoms of low testosterone such as decreased sexual desire and ability, extreme tiredness, low energy, depression, and loss of certain male characteristics such as muscular build and deep voice. How cernos gel works Cernos 1% w/w gel works by replacing testosterone that is normally produced in the body. Common side effects of cernos gel. Application site reactions (burning, irritation, itching and redness), Headache, Acne, Increased blood pressure.